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Code: f311
Latin name: Lepidorhombus whiffiagonis
Source material: Whole fish
Family: Bothidae
Megrim is also called white sole or whiff.

Allergen Exposure

Cooked or fried in various dishes.
Unexpected exposure
Inhalation of cooking steam.

Potential Cross-Reactivity

Species within groups of fish, like Gadiformes (examples: codfish and hake) and Scombroid fishes (examples: mackerel and tuna) seem to share allergenic components. The overlap of allergen specificity between the groups seems to be moderate or even small.

Clinical Experience

IgE-mediated reactions
The most common symptoms in a group of megrim-allergic children were urticaria and angioedema.

Asthma related to inhalation of cooking steam was reported.
Megrim, also called e.g. white sole or whiff, belongs to the order Pleuronectiformes and is one of the most frequently consumed fish in Spain.
In a study in children, the clinical symptoms induced by this fish allergy were urticaria and angioedema (92.4%) in 79 patients, followed by atopic dermatitis (17.7%) and inhalation-related asthma (13.9%) (1). In an immunoblot study of specific IgE binding, Megrim bound the greatest amount compared with the related sole and witch (1).


  1. Pascual, C; Martín Esteban, M; Fernández Crespo, J. Fish allergy: Evaluation of the importance of cross-reactivity. J Pediatr; 1992; 121: S29-34.


As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.