ImmunoCAP Specific IgG4

Quantifying IgG4 antibodies with ImmunoCAP Specific IgG4 results in proper evaluation of immunological response. Here you can learn more about the clinical value, expected test values and the test principle of ImmunoCAP Specific IgG4.

ImmunoCAP Specific IgG4 measures antigen specific IgG4 antibodies in human serum and plasma. Measurement of specific IgG4 antibodies have been used in clinical studies of different allergic diseases such as asthma, rhinitis, urticaria, eczema and gastrointestinal disorders. In monitoring immunotherapy, increased levels of specific IgG4 antibodies are generally seen.

Expected test values

There is no common cut-off value for specific IgG4 antibodies, as these are markers for antigen exposure and are not directly related to the disease. Results vary both within and between antigens. To determine if levels are increased, the reference level of specific IgG4 antibodies to a certain antigen must be measured in a number of samples from normal healthy persons and, if possible, compared with the levels in a group of patients.

Specimen collection and preparation

  • Collect blood samples and prepare serum or plasma according to standard procedures
  • Keep specimens at room temperature (RT) for shipping purposes only
  • Store at 2 °C to 8 °C for up to one week, otherwise store at –20 °C
  • Avoid repeated freezing and thawing

Important note

As in all diagnostic testing, a definitive clinical diagnosis should not be based solely on the results of a single test method. A diagnosis should be made by the physician after evaluation of all clinical and laboratory findings.


As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.