Latin name: Plantago lanceolata
Source material: rPla l 1 is a CCD-free recombinant protein.
Common names: Trypsin inhibitor
Allergen: rPla l 1. (1, 2)
rPla l 1 is a CCD-free recombinant protein.
Biological function: Trypsin inhibitor
Mw: 17-20 kDa
Pla l 1, a trypsin inhibitor, an Ole e 1-related protein, is a major specific English plantain allergen, recognised by approximately 85% of English plane-allergic patients. (1)
Recombinant Pla l 1, like other recombinant allergens, can be used to assess patient reactivity, characterise IgE binding epitopes, and study the effect of mutations on IgE binding.
See Plantain (English)/ Ribwort w9.
Pla l 1 is a trypsin inhibitor. (1, 2, 3, 4, 5, 6)
Trypsin inhibitors serve in certain plants as pathogenesis-related (PR) proteins which play an important role in the plant defence mechanism against insects and pathogens; (7) however their biological function in English plantain is unknown. They have been suggested to be involved in important events of pollen physiology, such as hydration, germination and/or pollen tube growth, and other reproductive functions. (8)
Pla I 1 and Ole e 1 share 39% of their amino acid sequences. Cross-reactivity using sera from patients allergic to either plant pollen was shown, and both allergens share common epitopes which are cross-recognised by sera from patients; (6) however, cross-reactivity with Ole e 1 is clinically non-significant and has little clinical relevance. (1, 2, 6, 9)
The Ole e 1-like family of proteins comprises allergenic members (Fra e 1, Lig v 1, Syr v 1 from Oleaceae species; Pla l 1 from Plantago lanceolata; Che a 1 from Chenopodium album; Lol p 11 from Lolium perenne; and Phl p 11 from Phleum pratense), as well as non-allergenic members such as BB18 from Betula verrucosa. (10)
English plantain pollen is an important cause of asthma, allergic rhinitis and allergic conjunctivitis, particularly in the temperate regions of North America, Australia and Europe. (11, 12, 13, 14, 15) English plantain pollen has also been shown to be present in relatively large amounts in various geographic regions of Europe, including Montpellier in France (16), Spain, (17, 18, 19) Poland, (20) Greece, (21) Turkey, (22, 23) Hungary, (24) and Israel. (25)
Pla l 1 is a major allergen, and Pla l 1-specific IgE is recognised in 80% to 86% of English plantain-sensitive patients. (1, 3)
See Plantain (English)/ Ribwort w9 for clinical information and further details on Plantain (English)/ Ribwort allergy.
Compiled by Dr Harris Steinman,
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- International Union of Immunological Societies Allergen Nomenclature: IUIS official list http://www.allergen.org/ Accessed December 2013.
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