Churg-Strauss Syndrome

The Churg-Strauss Syndrome, now Eosinophillic Glomerulonephritis with Polyangiitis (EGPA), initially reported under the descriptive title allergic granulomatosis and angiitis, is uncommon. Involvement of the lungs helps distinguish it from Polyarteritis nodosa.

This condition occurs in patients with asthma or a history of allergy. It usually develops in middle age and affects men more commonly than women.

In many patients, the disease follows a phasic pattern. Initially, an increase in allergic manifestations occurs, especially asthma, followed by eosinophilia and finally vasculitis. Fever, malaise, and weight loss are common early manifestations. As the vasculitis develops, asthma may become less prominent.

Cutaneous findings include petechiae, purpura, or ulcerations. Chest dicomfort or shortness of breath may result from pulmonary lesions. Peripheral neuropathy, usually multiple mononeuropathies, is common.

Abdominal symptoms include diarrhea pain, or a mass due to ischemia or infarction of abdominal organs. Renal lesions tend to be less severe than in Polyarteritis nodosa. Eosinophilic granulomatous involvement of the gastrointestinal and urinary tracts or prostate is a unique feature of this syndrome.


As in all diagnostic testing, the diagnosis is made by the physican based on both test results and the patient history.