ImmunoCAP Specific IgG measures antigen-specific IgG antibodies in human serum and plasma. Specific IgG comprises antigen-specific antibodies of immunoglobulin class G. These antibodies are part of the natural defense system of the body and develop in response to contact with foreign substances.
The presence of IgG antibodies specific to a certain antigen is a marker of exposure to that antigen. Furthermore, the level of specific IgG in serum usually reflects the extent of exposure to that antigen. Measuring specific IgG antibodies may provide a range of valuable clinical information in several fields.
Allergic disease
For example, in research applications associated with allergic disease, specific IgG is used:
- In clinical studies of asthma, rhinitis, urticaria, eczema and gastrointestinal disorders
- As a marker for exposure in different lung diseases, e.g. allergic alveolitis, aspergilloma and aspergillosis
- In monitoring immunotherapy, increased levels of specific IgG may be correlated with clinical outcomes