Goodpasture's syndrome

Goodpasture's syndrome, a disease of unknown origin, is characterized by the triad of pulmonary haemorrhage, glomerulonephritis and circulating antibody to basement membrane antigens. Intrapulmonary haemorrhage may be insignificant or severe and life-threatening, often preceding renal involvement by 1-12 months. Renal involvement is commonly rapidly progressive, with oliguric renal failure occurring within weeks to months of the clinical onset of the disease. Without early treatment, permanent renal failure is the rule.